The goal of our research is to understand how proliferation of the cell, "Cell Cycle", is regulated in concert with developmental and homeostatic processes in multicellular organisms, with an ultimately aim to apply the knowledge gained to improve human health. By harnessing the powerful genetics of the fruit fly Drosophila melanogaster, in combination with cutting-edge biochemisty and bioimaging methods and mammalian cell/tissue engineering, we are investigating molecular mechanisms that coordinate cell division with cell differentiation and tissue formation at multiple levels: from molecule, cell, tissue to organism.
Roles of cell cycle regulator proteins in cell fate decision
Metazoan cell cycle regulator proteins (CCRs) often possess molecular capacities that directly influence cell fate choice and/or subsequent differentiation processes, in addition to their cell cycle function. We are exploring novel functions of conserved CCRs in cell fate decision by tissue-specific genetic screens and proteomics and genomics analyses in Drosophila and mammalian cells.
Cell cycle regulation in cellular quiescence
It is poorly understood how metazoan cells make a decision on whether to continue dividing, or to stop to divide entering cellular quiescence, G0 phase, upon a withdrawal of mitogenic signals. We are investigating molecular mechanisms through which cells enter or stay in G0 phase in response to mitogen depletion in vivo or in culture, using Drosophila progenitor cells and human cells.
Crosstalk between cell cycle machinery and the centrosome
The centrosome is an organelle present in the majority of animal cells that regulates various cellular events, such as chromosome segregation, cell polarity, cell migration and intracellular transport, through microtubule nucleation. We are investigating molecular interactions between CCRs and centrosome components and the role of their crosstalk in organ development and genome maintenance in Drosophila.
Yuu were invited to give an online lecture at Hiroshima Research Center for Healthy Aging (HiHA) at Hiroshima University. It was the first time for me to give a seminar in Japanese for the last 10 or more years. But at the end it went well and was a great fun. Thank the host, Prof. […]
Yesterday, our senior lab member, Luke (Rusong Ding, 3rd year M.Phil) took Yuu’s position to give an introduction of our research to newly enrolled graduate students in the laboratory introduction session. Luke gave an amazing presentation, passionate and inspiring, which caught the hearts of many newly arrived students. Thanks to his presentation, the highest number […]
Our collaborator, Dr Takashi Ochi (University of Leeds), published a new article on CCDC61/VFL3, a component of the centriole and the primary cilium, in the journal of Structure. Through computation analyses of 3D protein structures, Dr Ochi previously identified a new protein superfamily consisting of the DNA damage repair proteins XRCC4, XLF and PAXX and […]
We would like to thank our principal funder Cancer Research UK, as well as BBSRC and the Europan Commission for the research support we have received.